I read an interesting Fortune magazine article that profiles Sirtris, a startup company that is trying to develop age slowing technologies based on the recent discoveries about resveratrol.
What’s resveratrol? As the magazine article states:
Resveratrol is the ingredient in red wine that made headlines in November [2006] when scientists demonstrated that it kept overfed mice from gaining weight, turned them into the equivalent of Olympic marathoners, and seemed to slow down their aging process. Few medical discoveries have generated so much instant buzz - even Jay Leno riffed about it in his opening monologue.
Prior to this new research on resveratrol, the one known way in mammals to slow down some of the markers of aging has been caloric restriction. Caloric restriction has certainly worked in lower order mammals, but large scale human studies have yet to be completed. Even if caloric restriction was shown to work in people, it would probably be difficult for people to have the discipline to do, since it effects lifestyle pretty significantly.
The Fortune article stated something interesting about resveratrol’s relation to caloric restriction:
The mouse studies [examining the effect of resveratrol] also gave hints that resveratrol induces basic metabolic changes akin to those that [caloric restriction] does. One of the most intriguing was the production of fresh mitochondria, the key components of cells that serve as power generators; they essentially burn sugar in slow motion to release energy. But like coal-burning power plants, mitochondria also pollute. In particular, they spew highly reactive chemicals called free radicals, which damage DNA and other important molecules in cells. Over time the radicals deteriorate the mitochondria themselves, which degrades their efficiency, causing yet heavier production of free radicals. The end result is a cell-degrading snowball effect that is thought to be a major cause of aging.
Here’s the entire Fortune article:
http://money.cnn.com/2007/01/18/magazines/fortune/Live_forever.fortune/index.htm